Bepotastine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Bepotastine free base 是一种组胺 1 (H1) 受体拮抗剂。

Bepotastine free base is a histamine 1 (H1) receptor antagonis.

Bepotastine (10, 100, 1000 μM; preincubates for 120 min) decreases the release of histamine induced by A23187 treatment, which reaches a statistically significant reduces level at 1000 μM.Bepotastine (50 μM; 1 h) suppresses the expression of NGF mRNA in NHEKs.Cell Viability Assay Cell Line:RPMCs Concentration:10, 100, 1000 μM Incubation Time:120 min (preincubate)Result:Decreased the release of histamine.Western Blot Analysis Cell Line:NHEKs Concentration:50 μM (preincubation)Incubation Time:1 hResult:Suppressed the expression of NGF mRNA in NHEKs.

Bepotastine (10 g/L; eye drop; 3 times at intervals of 20 min in one eye) demonstrates significant inhibition of PAF-induced conjunctival eosinophil infiltration.Bepotastine (3 mg/kg; p.o.; once) suppresses scratching behavior to a frequency of 59.0 and a duration of 14.57 seconds, which are almost the same levels compares with the control.Bepotastine (10 mg/kg; p.o.; once) significantly suppresses serum LTB 4 levels to 711.3 pg/mL at 1 h and 858.8 pg/mL at 2 h in NC/Nga mice with a rash. Animal Model:Guinea pigs (6-week-old).Dosage:10 g/L (1.0% (w/v)) for 10 μL.Administration:Eye drop; 3 times at intervals of 20 min (in one eye).Result:Inhibited PAF-induced conjunctival eosinophil infiltration.Animal Model:Male BALB/c mice(12-week-old); NC/Nga mice.Dosage:3, 10 mg/kg Administration:Oral administration; once (1 h before induces scratching behavior of Male BALB/c mice).Result:Significantly inhibited histamine-mediated scratching behavior in male BALB/c mice.Significantly suppressed serum LTB 4 levels in NC/Nga mice with a rash.

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Others

Other Targets

others

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125602-71-3

388.89

C21H25ClN2O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (257.14 mM)

O=C(O)CCCN1CCC(OC(c2ccc(Cl)cc2)c2ccccn2)CC1

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(-20℃)

With Ice Pack

≥ 2 years